A simple, precise, accurate and reproducible spectrophotometric method has been developed for simultaneous estimation of Aspirin and Esomeprazole Magnesium by employing first order derivative zero crossing method in methanol. The first order derivative absorption at 313 nm (zero cross point of aspirin) was used for quantification of Esomeprazole Magnesium and 236 nm (zero cross point of Esomeprazole Magnesium) for quantification of aspirin. The linearity was established over the concentration range of 10-60 μg/ml and 10-60 μg/ml for Esomeprazole Magnesium and Aspirin with correlation coefficient r 2 0.9974 and 0.9977, respectively. The mean % recoveries were found to be in the range of 99.7 – 99.9 % and 99.6 – 100.10 % for Esomeprazole Magnesium and aspirin, respectively. The proposed method has been validated as per ICH guidelines and successfully applied to the estimation of Esomeprazole Magnesium and aspirin in their combined Tablet dosage form.
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